Broadway opened just 20 shows in 2021, but the ones that did open stayed: half of those runs lasted 60 performances or more.
2021
32 shows opened on Broadway and in the West End in 2021.
SIX: The Musical, by Toby Marlow & Lucy Moss, opened in 2021 at Brooks Atkinson Theatre and ran 1,200 performances.
Opened in 2021
UndatedJuneAugustSeptemberOctoberNovemberDecember
Undated: 12 openings
| Unknown | An Audience with Adele London Palladium, London | |
| Unknown | Four Quartets Harold Pinter Theatre, London | |
| Unknown | Jersey Boys Trafalgar Theatre, London | |
| Unknown | Joseph and the Amazing Technicolor Dreamcoat London Palladium, London | |
| Unknown | Life of Pi Wyndham's Theatre, London | |
| Unknown | Little Women London, London | |
| Unknown | Magic Goes Wrong 2022 Apollo Theatre, London | |
| Unknown | Six Vaudeville Theatre, London | |
| Unknown | SIX: The Musical Brooks Atkinson Theatre, Broadway | 1,200 perf. |
| Unknown | The Mirror and the Light Gielgud Theatre, London | |
| Unknown | The Ocean at the End of the Lane Tom Stoppard Theatre, London | |
| Unknown | The Windsors Endgame Prince of Wales Theatre, London |
June: 1 opening
| June 26, 2021 | Springsteen on Broadway St James Theatre, Broadway | 30 perf. |
August: 1 opening
| August 22, 2021 | Pass Over August Wilson Theatre, Broadway | 57 perf. |
September: 2 openings
| September 2, 2021 | Waitress Ethel Barrymore Theatre, Broadway | 122 perf. |
| September 23, 2021 | Mean Girls , London |
October: 9 openings
| October 7, 2021 | Lackawanna Blues Samuel J Friedman Theatre, Broadway | 27 perf. |
| October 10, 2021 | Chicken & Biscuits Circle In The Square Theatre, Broadway | 41 perf. |
| October 11, 2021 | Is This a Room Lyceum Theatre, Broadway | 26 perf. |
| October 13, 2021 | Thoughts of a Colored Man John Golden Theatre, Broadway | 77 perf. |
| October 14, 2021 | The Lehman Trilogy Nederlander Theatre, Broadway | 82 perf. |
| October 17, 2021 | American Utopia St James Theatre, Broadway | 134 perf. |
| October 17, 2021 | Dana H. Lyceum Theatre, Broadway | 25 perf. |
| October 19, 2021 | Freestyle Love Supreme Booth Theatre, Broadway | 84 perf. |
| October 27, 2021 | Caroline, or Change Studio 54, Broadway | 85 perf. |
November: 3 openings
| November 17, 2021 | Diana Longacre Theatre, Broadway | 33 perf. |
| November 18, 2021 | Trouble in Mind American Airlines Theatre, Broadway | 58 perf. |
| November 23, 2021 | Clyde's Hayes Theater, Broadway | 62 perf. |
December: 4 openings
| December 2, 2021 | Slave Play August Wilson Theatre, Broadway | 57 perf. |
| December 5, 2021 | Mrs. Doubtfire Stephen Sondheim Theatre, Broadway | 381 perf. |
| December 6, 2021 | Flying Over Sunset Vivian Beaumont Theater, Broadway | 37 perf. |
| December 9, 2021 | Company Bernard B. Jacobs Theatre, Broadway | 300 perf. |
Closed in 2021
| December 17, 2021 | Jagged Little Pill Broadhurst Theatre, opened 2019 | 327 run |